Degradation of chlorambucil in aqueous solution

H Ehrsson, S Eksborg, I Wallin…

Index: Ehrsson; Eksborg; Wallin; Nilsson Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 9 p. 1091 - 1094

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Citation Number: 33

Abstract

Abstract The stability of chlorambucil and its degradation product 4-[p-(2-chloroethyl-2- hydroxyethylamino) phenyl] butyric acid (I) was studied using reversed-phase high-pressure liquid chromatography. The degradation rate of chlorambucil was unaffected by pH between pH 5 and 10 but decreased at lower pH. The degradation rates of chlorambucil and I differed only slightly (pH> 6). The proteolytic properties of the compounds were studied using ...