e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

General method of diastereo-and enantioselective synthesis of β-hydroxy-α-amino acids by condensation of aldehydes and ketones with glycine

YN Belokon, AG Bulychev, SV Vitt…

Index: Journal of the American Chemical Society, , vol. 107, # 14 p. 4252 - 4259

Full Text: HTML

Citation Number: 173

Abstract

... 0002-7863/85/1507-4252$01,50/0 0 1985 American Chemical Society Page 2. ... An important advantage of this reaction is its high diastereo- and enantioselectivity which permit us to obtain almost pure (R)-threo-3 with an ee greater than 80%. ... J. Am. Chem. Soc., Vol, 107, No. ...

Formaldehyde Structure

(S)-2,4-DIACETOXY-1-BROMOBUTANE Structure

(S)-2,4-DIACETO...

Glycine Structure

~%

D-serine Structure

Detail

Formaldehyde Structure

(S)-2,4-DIACETOXY-1-BROMOBUTANE Structure

(S)-2,4-DIACETO...

Glycine Structure

~%

D-serine Structure

Detail

Formaldehyde Structure

(S)-2,4-DIACETOXY-1-BROMOBUTANE Structure

(S)-2,4-DIACETO...

Glycine Structure

~%

D-serine Structure

Detail

1-Benzyl-L-proline Structure

1-Benzyl-L-proline

~%

1-benzyl-pyrrolidine-2-carboxylic acid hydrochloride Structure

1-benzyl-pyrrol...

piperonal Structure

(S)-2,4-DIACETOXY-1-BROMOBUTANE Structure

(S)-2,4-DIACETO...

Glycine Structure

~%

(S)-(+)-2-Amino-3-hydroxy-3-methylbutanoic acid Structure

(S)-(+)-2-Amino...

Detail

(S)-2,4-DIACETOXY-1-BROMOBUTANE Structure

(S)-2,4-DIACETO...

Acetone Structure

Glycine Structure

~%

(S)-(+)-2-Amino-3-hydroxy-3-methylbutanoic acid Structure

(S)-(+)-2-Amino...

Detail

Formaldehyde Structure

(S)-2,4-DIACETOXY-1-BROMOBUTANE Structure

(S)-2,4-DIACETO...

Glycine Structure

~%

D-serine Structure

Detail

Formaldehyde Structure

(S)-2,4-DIACETOXY-1-BROMOBUTANE Structure

(S)-2,4-DIACETO...

Glycine Structure

~%

D-serine Structure

Detail

(S)-2,4-DIACETOXY-1-BROMOBUTANE Structure

(S)-2,4-DIACETO...

ch3cho Structure

Glycine Structure

~%

H-Allo-Thr-OH Structure

Detail

Catalytic Hydrogenation of Chiral α??Amino and α??Hydroxy Es...

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