«Push??Pull»??Acetylene als Hilfsmittel zur Synthese von Amiden

M Neuenschwander, U Lienhard…

Index: Neuenschwander,M. et al. Helvetica Chimica Acta, 1978 , vol. 61, p. 2428 - 2436

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Citation Number: 12

Abstract

Summary 'Push-pull'-acetylenes react easily with carbon acids. Addition of amines to the crude reaction mixture gives amides in an excellent yield by a simple one-pot procedure. Because of the high selectivity of the acetylenes 1 towards carboxylic functions and of the high selectivity of the enol esters 4 towards amine functions,'pushpull'-acetylenes could be excellent reagents for peptide synthesis.