The Journal of Organic Chemistry

Gas-phase synthesis of nitriles

RJ Card, JL Schmitt

Index: Card, Roger J.; Schmitt, J. Lawrence Journal of Organic Chemistry, 1981 , vol. 46, p. 754 - 757

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Citation Number: 38

Abstract

n-Octanenitrile is obtained in 87% yield from the copper-catalyzed, gas-phase reaction of 1- octanol with ammonia at 325" C and 1 atm. Similar high yields of alkyl or aryl nitriles are obtained from the reaction of ammonia with primary alcohols, aldehydes, primary amines, secondary amines, and esters. The effect of reaction variables is examined: highest yields of nitriles are obtained when the reaction is carried out at ca. 300 OC and at ammonia to ...