The Journal of organic chemistry

One-pot anti-Markovnikov hydroamination of unactivated alkenes by hydrozirconation and amination

AE Strom, JF Hartwig

Index: Strom, Alexandra E.; Hartwig, John F. Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8909 - 8914

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Citation Number: 19

Abstract

A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography.