[(3-Chlorophenyl) piperazinylpropyl] pyridazinones and analogues as potent antinociceptive agents

MP Giovannoni, C Vergelli, C Ghelardini…

Index: Journal of Medicinal Chemistry, , vol. 46, # 6 p. 1055 - 1059

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Citation Number: 83

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The synthetic pathway affording the final 5−8 is depicted in Scheme 1. With the exception of 3c and 4c, the isoxazoles 3 and the isoxazolo[3,4-d]pyridazinones 4 were previously described. ...

An improved procedure for the lateral lithiation of ethyl 4-...

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Microwave accelerated synthesis of isoxazole hydrazide inhib...

[Matti, Afnan A.; Mirzaei, Joseph; Rudolph, John; Smith, Stephen A.; Newell, Jayme L.; Patel, Sarjubhai A.; Braden, Michael R.; Bridges, Richard J.; Natale, Nicholas R. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5931 - 5935]

Lateral lithiation of ethyl 4-acetyl-5-methyl-3-isoxazolyl c...

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Base??and Copper??Catalysed Condensation of Primary Activate...

[Trogu, Elena; Cecchi, Luca; De Sarlo, Francesco; Guideri, Luca; Ponticelli, Fabio; Machetti, Fabrizio European Journal of Organic Chemistry, 2009 , # 34 p. 5971 - 5978]