An asymmetric hydroformylation catalyst that delivers branched aldehydes from alkyl alkenes

GM Noonan, JA Fuentes, CJ Cobley…

Index: Noonan, Gary M.; Fuentes, Jose A.; Cobley, Christopher J.; Clarke, Matthew L. Angewandte Chemie - International Edition, 2012 , vol. 51, # 10 p. 2477 - 2480

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Citation Number: 65

Abstract

Enantioselective hydroformylation of alkenes can simultaneously create a new CÀC bond, install a very versatile functional group, and produces enantiomerically enriched compounds from very economic reagents: an alkene, carbon monoxide, and hydrogen. Given the precedent for large-scale production of achiral linear aldehydes, hydroformylation can be viewed as potentially the ideal reaction for commercial production of chiral building blocks ...