Pd??Catalyzed Cross??Coupling Reactions with Carbonyls: Application in a Very Efficient Synthesis of 4??Aryltetrahydropyridines

…, M Tomás??Gamasa, P Moriel, F Aznar…

Index: Barluenga, Jose; Tomas-Gamasa, Maria; Moriel, Patricia; Aznar, Fernando; Valdes, Carlos Chemistry - A European Journal, 2008 , vol. 14, # 16 p. 4792 - 4795

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Citation Number: 84

Abstract

Palladium-catalyzed couplings are very powerful tools for the formation of CÀC linkages.[1] A typical cross-coupling reaction involves the combination of an electrophile with a nucleophile in the presence of a metal catalyst. The classical nucleophilic components are organometallic reagents derived from, for example, magnesium,[2] boron,[3] silicon,[4] tin,[5] and zinc,[6] whereas the electrophiles are generally organic halides or sulfonates. Thus, a ...