Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers

G Chen, H Xia, Y Cai, D Ma, J Yuan, C Yuan

Index: Chen, Gang; Xia, Hongguang; Cai, Yu; Ma, Dawei; Yuan, Junying; Yuan, Chengye Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 234 - 239

Full Text: HTML

Citation Number: 10

Abstract

A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d–e, 15i–j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.