Palladium/Copper??Catalyzed Di?螃窿?arylation of Acetic Acid Esters

B Song, T Himmler, LJ Goossen

Index: Song, Bingrui; Himmler, Thomas; Goossen, Lukas J. Advanced Synthesis and Catalysis, 2011 , vol. 353, # 10 p. 1688 - 1694

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Citation Number: 9

Abstract

Abstract A bimetallic palladium/copper catalyst system was found to effectively promote the diarylation of alkyl acetates with aryl halides under unprecedentedly mild conditions. The phenanthroline-copper-phosphine catalyst stabilizes the enolate intermediate to the extent that the deprotonation of esters can be achieved even with the mild base potassium phosphate. The palladium tri-tert-butylphosphine co-catalyst mediates the coupling of the ...