Tetrahedron letters

Lipase catalyzed synthesis of macrocyclic lactones in organic solvents

A Makita, T Nihira, Y Yamada

Index: Makita, Atushi; Nihira, Takuya; Yamada, Yasuhiro Tetrahedron Letters, 1987 , vol. 28, # 7 p. 805 - 808

Full Text: HTML

Citation Number: 126

Abstract

Abstract A new method for the preparation of macrocyclic lactones from ω-hydroxyacid methyl esters is described. The approach utilizes intramolecular transesterification catalyzed by lipase in organic solvents. This procedure is also applicable to the synthesis of asymmetric lactones.