Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists

S Sasmal, G Balaji, HRK Reddy…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 9 p. 3157 - 3162

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Citation Number: 33

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... As will become apparent we lost in affinity for the MCH1 receptor by this scaffold switch which called for additional SAR explorations of the eastern side chain that are described in this Letter leading up to a molecule with good efficacy ...

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A reliable and efficient synthesis of SR 142801

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Synthesis and structure–activity relationships of 4-hydroxy-...

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(3R)-3-Amino-4-(2, 4, 5-trifluorophenyl)-N-{4-[6-(2-methoxye...

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