molecules

Synthesis of 5-substituted 3-amino-1H-pyrazole-4-carbonitriles as precursors for microwave assisted regiospecific syntheses of pyrazolo [1, 5-a] pyrimidines

F Al-Qalaf, F Mandani, MM Abdelkhalik, AA Bassam

Index: Al-Qalaf, Fawzia; Mandani, Faisal; Abdelkhalik, Mervat Mohammed; Bassam, Abeer Abdulrahman Molecules, 2009 , vol. 14, # 1 p. 78 - 88

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Citation Number: 9

Abstract

Abstract: A simple route to 3-oxoalkanonitrile 5, a precursor of the title compounds is described. Reaction of enaminones 2 with hydroxylamine hydrochloride in ethanol yielded aldoximes 3 that were converted readily into 5 in basic medium. This method has been successfully applied with a number of substrates and resulted in excellent yields of the products. Reacting 5 with trichloroacetonitrile afforded 3-amino-2-aroyl-4, 4, 4-trichloro-2- ...