Chemical Communications

Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate …

RG Bhat, S Sinha, S Chandrasekaran

Index: Bhat, Ramakrishna G.; Sinha, Surajit; Chandrasekaran, Srinivasan Chemical Communications, 2002 , # 8 p. 812 - 813

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Citation Number: 16

Abstract

However, in recent years the use of Fmoc amino acid chlorides, 3 Fmoc amino acid fluorides 4 and N-Bts protected amino acid chlorides 5 have found use in the racemisation-free synthesis of peptides in high yield. The limitation of these methods is the use of basic or harsher acidic conditions that are used for the N-deprotection which leads to undesired by-products. ... Herein we report the use of a propargyloxycarbonyl (Poc) group as a novel N-protecting group, ...