Synthesis and Purification of 6-Ethoxy-4-oxo-1, 4-dihydro-[1, 5] naphthyridine-3-carboxylic Acid Benzylamide

J Beaudin, DE Bourassa, P Bowles…

Index: Beaudin, Justin; Meltz, Clifford N.; Meltz, Morgan; Phillips, James E.; Ragan, John A.; Brown Ripin, David H.; Singer, Robert A.; Tucker, John L.; Wei, Lulin; Bourassa, Dennis E.; Bowles, Paul; Castaldi, Michael J.; Clay, Ronald; Couturier, Michel A.; Karrick, Gregory; Makowski, Teresa W.; McDermott, Ruth E. Organic Process Research and Development, 2003 , vol. 7, # 6 p. 873 - 878

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Citation Number: 14

Abstract

The synthesis of 6-ethoxy-4-oxo-1, 4-dihydro-[1, 5] naphthyridine-3-carboxylic acid benzylamide (1) on multikilogram scale is described. The major challenge for the synthesis of this quinolone GABA partial agonist was in the isolation of product of acceptable purity ...