Synthesis and Purification of 6-Ethoxy-4-oxo-1, 4-dihydro-[1, 5] naphthyridine-3-carboxylic Acid Benzylamide

J Beaudin, DE Bourassa, P Bowles…

文献索引：Beaudin, Justin; Meltz, Clifford N.; Meltz, Morgan; Phillips, James E.; Ragan, John A.; Brown Ripin, David H.; Singer, Robert A.; Tucker, John L.; Wei, Lulin; Bourassa, Dennis E.; Bowles, Paul; Castaldi, Michael J.; Clay, Ronald; Couturier, Michel A.; Karrick, Gregory; Makowski, Teresa W.; McDermott, Ruth E. Organic Process Research and Development, 2003 , vol. 7, # 6 p. 873 - 878

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被引用次数: 14

摘要

The synthesis of 6-ethoxy-4-oxo-1, 4-dihydro-[1, 5] naphthyridine-3-carboxylic acid benzylamide (1) on multikilogram scale is described. The major challenge for the synthesis of this quinolone GABA partial agonist was in the isolation of product of acceptable purity ...