Demonic axe-like conjugated alkynes in combating microbes

…, S Koppireddi, S Avula, PK Koochana, R Yadla

Index: Komsani, Jayaram Reddy; Koppireddi, Satish; Avula, Sreenivas; Koochana, Pranay Kumar; Yadla, Rambabu European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 132 - 138

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Abstract

Abstract A new series of disubstituted alkynes was obtained by microwave induced internal splitting of the corresponding β-oxo-alkylidenetriphenylphosphoranes. The antimicrobial potential of these conjugated alkynes and phosphoranes was assayed in vitro against three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, Staphylococcus epidermidis), three Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, ...