e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

The Synthesis of Thyromimetic Substances and Potential Inhibitors of Thyroxine1

CM Buess, T Giudici, N Kharasch, W King…

Index: Buess,C.M. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 469 - 474

Full Text: HTML

Citation Number: 13

Abstract

In a previous the basis for our approach to the synthesis of thyroxine analogs and potential inhibitors of thyroxine was summarized. The syntheses of eight novel analogs, Ia-d, IIa-c, and I11 are now reported; the synthetic scheme for Id was briefly communicated previously. 3 In view of current theories of thyroxine action and results of testing, the choice of compounds was made on the basis of the postulated relation between activity and ...

Ethanol Structure

L-Tyrosine Structure

Acetyl chloride Structure

Acetyl chloride

~%

AC-3,5-DINITRO-TYR-OET Structure

AC-3,5-DINITRO-...

4-Benzyloxyphenol Structure

4-Benzyloxyphenol

~%

3,5-Diiodothyropropionic Acid Structure

3,5-Diiodothyro...

Phenol,4-(phenylmethoxy)-, 1-benzoate Structure

Phenol,4-(pheny...

~%

3,5-Diiodothyropropionic Acid Structure

3,5-Diiodothyro...

4-hydroxyphenyl benzoate Structure

4-hydroxyphenyl...

~%

3,5-Diiodothyropropionic Acid Structure

3,5-Diiodothyro...

Hydroquinone Structure

~%

3,5-Diiodothyropropionic Acid Structure

3,5-Diiodothyro...

4-Benzyloxyphenol Structure

4-Benzyloxyphenol

~%

4-(4-Hydroxyphenoxy)-3,5-diiodobenzoic acid Structure

4-(4-Hydroxyphe...

Phenol,4-(phenylmethoxy)-, 1-benzoate Structure

Phenol,4-(pheny...

~%

4-(4-Hydroxyphenoxy)-3,5-diiodobenzoic acid Structure

4-(4-Hydroxyphe...

4-[4-Benzoyloxy-phenoxy]-3.5-dijod-benzoesaeure-aethylester Structure

4-[4-Benzoyloxy...

~%

4-(4-Hydroxyphenoxy)-3,5-diiodobenzoic acid Structure

4-(4-Hydroxyphe...

4-hydroxyphenyl benzoate Structure

4-hydroxyphenyl...

~%

4-(4-Hydroxyphenoxy)-3,5-diiodobenzoic acid Structure

4-(4-Hydroxyphe...

ethyl 4-hydroxy-3,5-dinitro-benzoate Structure

ethyl 4-hydroxy...

~%

4-(4-Hydroxyphenoxy)-3,5-diiodobenzoic acid Structure

4-(4-Hydroxyphe...

4-(4-Benzoyloxy-phenoxy)-3.5-dinitro-benzoesaeure-aethylester Structure

4-(4-Benzoyloxy...

~%

4-(4-Hydroxyphenoxy)-3,5-diiodobenzoic acid Structure

4-(4-Hydroxyphe...

Hydroquinone Structure

~%

4-(4-Hydroxyphenoxy)-3,5-diiodobenzoic acid Structure

4-(4-Hydroxyphe...

4-Hydroxybenzoic acid Structure

4-Hydroxybenzoi...

~%

4-(4-Hydroxyphenoxy)-3,5-diiodobenzoic acid Structure

4-(4-Hydroxyphe...

Ethanol Structure

4-Hydroxybenzoic acid Structure

4-Hydroxybenzoi...

~%

ethyl 4-hydroxy-3,5-dinitro-benzoate Structure

ethyl 4-hydroxy...

2,6-Di-tert-butyl-p-benzoquinone Structure

2,6-Di-tert-but...

~%

Phenol,2,6-bis(1,1-dimethylethyl)-4-(phenylmethoxy)- Structure

Phenol,2,6-bis(...

2,6-di-tert-butylhydroquinone Structure

2,6-di-tert-but...

Benzyl chloride Structure

Benzyl chloride

~%

Phenol,2,6-bis(1,1-dimethylethyl)-4-(phenylmethoxy)- Structure

Phenol,2,6-bis(...

4-Benzyloxyphenol Structure

4-Benzyloxyphenol

~%

3,5-diiodo-dl-thyronine Structure

3,5-diiodo-dl-t...

Phenol,4-(phenylmethoxy)-, 1-benzoate Structure

Phenol,4-(pheny...

~%

3,5-diiodo-dl-thyronine Structure

3,5-diiodo-dl-t...

N/A Structure

~%

3,5-diiodo-dl-thyronine Structure

3,5-diiodo-dl-t...

4-hydroxyphenyl benzoate Structure

4-hydroxyphenyl...

~%

3,5-diiodo-dl-thyronine Structure

3,5-diiodo-dl-t...

AC-3,5-DINITRO-TYR-OET Structure

AC-3,5-DINITRO-...

~%

3,5-diiodo-dl-thyronine Structure

3,5-diiodo-dl-t...

N-acetyl-O'-benzoyl-3,5-dinitro-L-thyronine ethyl ester Structure

N-acetyl-O'-ben...

~%

3,5-diiodo-dl-thyronine Structure

3,5-diiodo-dl-t...

L-Tyrosine Structure

~%

3,5-diiodo-dl-thyronine Structure

3,5-diiodo-dl-t...

Hydroquinone Structure

~%

3,5-diiodo-dl-thyronine Structure

3,5-diiodo-dl-t...