The effects of lysine N ε-trimethylation at selected positions of the antimicrobial cecropin A− melittin hybrid peptide KWKLFKKIGAVLKVL-amide have been studied. All five monotrimethylated, four bis-trimethylated plus the per-trimethylated analogues have been synthesized and tested for antimicrobial activity on Leishmania parasites and on Gram- positive and-negative bacteria, as well as for hemolysis of sheep erythrocytes as a ...
