Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl) adenosines: adenosine A2 receptor agonists with potent antihypertensive effects

…, T Miyashita, Y Watanabe, T Yamaguchi…

Index: Abiru; Miyashita; Watanabe; Yamaguchi; Machida; Matsuda Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2253 - 2260

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Citation Number: 59

Abstract

Adenosine receptor-binding profiles in rat brain tissues and antihypertensive effecta in spontaneously hypertensive rata (SHR) of a series of 2-(cycloalkylalkyny1) adenosines (2- CAAs) and their congeners are described. The structure-activity relationship of this series of compounds is discussed, focusing on the length of the alkynyl side chain and bulkiness of the terminal cycloalkyl substituents in terms of binding activity and cardiovascular effecta. ...