Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl) adenosines: adenosine A2 receptor agonists with potent antihypertensive effects

…, T Miyashita, Y Watanabe, T Yamaguchi…

文献索引：Abiru; Miyashita; Watanabe; Yamaguchi; Machida; Matsuda Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2253 - 2260

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被引用次数: 59

摘要

Adenosine receptor-binding profiles in rat brain tissues and antihypertensive effecta in spontaneously hypertensive rata (SHR) of a series of 2-(cycloalkylalkyny1) adenosines (2- CAAs) and their congeners are described. The structure-activity relationship of this series of compounds is discussed, focusing on the length of the alkynyl side chain and bulkiness of the terminal cycloalkyl substituents in terms of binding activity and cardiovascular effecta. ...