Highly practical methodology for the synthesis of d-and l-α-amino acids, N-protected α-amino acids, and N-methyl-α-amino acids

AG Myers, JL Gleason, T Yoon…

Index: Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung; Kung, Daniel W. Journal of the American Chemical Society, 1997 , vol. 119, # 4 p. 656 - 673

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Citation Number: 201

Abstract

Full details are provided for an exceedingly practical method to synthesize d-and l-α-amino acids, N-protected α-amino acids, and N-methyl-α-amino acids, employing as a key step the asymmetric alkylation of pseudoephedrine glycinamide (1) or pseudoephedrine sarcosinamide (2). Practical procedures for the synthesis of 1 and 2 from pseudoephedrine and glycine methyl ester or sarcosine methyl ester, respectively, are presented. Optimum ...