Novel AMPA Receptor Antagonists: Synthesis and Structure-Activity Relationships of 1-Hydroxy-7-(1 H-imidazol-1-yl)-6-nitro-2, 3 (1 H, 4 H)-quinoxalinedione …

J Ohmori, M Shimizu-Sasamata, M Okada…

Index: Ohmori; Kubota; Shimizu-Sasamata; Okada; Sakamoto Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1331 - 1338

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Citation Number: 85

Abstract

As part of our study of novel antagonists at the α-amino-3-hydroxy-5-methylisoxazole-4- propionate (AMPA) subtype of excitatory amino acid (EAA) receptors and the pharmacophoric requirements of the receptor, we designed and synthesized a series of 1- substituted 6-imidazolyl-7-nitro-, and 7-imidazolyl-6-nitroquinoxalinediones, as well as related compounds, 6a-j, 7, 11a-e, 15, and 17, which are 1-and 4-substituted analogues of ...