Synthesis of a peptide nucleic acid with a novel 1??methyl??6??mercaptopurine base

T Aboul??Fadl, G Rajeev…

Index: Aboul-Fadl, Tarek; Rajeev, Gopalan; Broom, Arthur D. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 2 p. 445 - 451

Full Text: HTML

Citation Number: 2

Abstract

Peptide nucleic acids (PNAs) are nucleic acid mimics that have potential for modulating gene expression via antisense or antigene mechanism or can be used as diagnostic and molecular biology tools [3, 4]. Moreover, PNAs may also find various interesting applications in chemistry and technology, eg. as electrochemical biosensors, and in optical data storage [5-7]. In PNA the deoxyribose phosphate backbone of the nucleic acid is replaced by a ...