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Synthesis of a peptide nucleic acid with a novel 1??methyl??6??mercaptopurine base

T Aboul??Fadl, G Rajeev…

文献索引:Aboul-Fadl, Tarek; Rajeev, Gopalan; Broom, Arthur D. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 2 p. 445 - 451

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被引用次数: 2

摘要

Peptide nucleic acids (PNAs) are nucleic acid mimics that have potential for modulating gene expression via antisense or antigene mechanism or can be used as diagnostic and molecular biology tools [3, 4]. Moreover, PNAs may also find various interesting applications in chemistry and technology, eg. as electrochemical biosensors, and in optical data storage [5-7]. In PNA the deoxyribose phosphate backbone of the nucleic acid is replaced by a ...