Synthesis

The synthesis of 5-substituted 2, 3-dihydrobenzofurans

RJ Alabaster, IF Cottrell, H Marley, SHB Wright

Index: Alabaster, Ramon J.; Cottrell, Ian F.; Marley, Hugh; Wright, Stanley H. B. Synthesis, 1988 , # 12 p. 950 - 952

Full Text: HTML

Citation Number: 10

Abstract

The preparation of 2, 3—dihydrobenzofurans 6 from 2—(2—bromophen—oxy) ethyl chlorides 3 by reaction with magnesium in a development of the Parham cyclialkylation reaction is described. A high yielding proce-dure using phase-transfer catalysis has also been developed for the preparation of the intermediate chloroethyl ethers 3 from bromo— phenols 2. The 5—hydroxy derivative 15 may be obtained from 2, 3—dihydrobenzofuran ( ...

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