Synthesis of the Transfer??RNA Nucleoside Queuosine by Using a Chiral Allyl Azide Intermediate

F Klepper, EM Jahn, V Hickmann…

Index: Klepper, Florian; Jahn, Eva-Maria; Hickmann, Volker; Carell, Thomas Angewandte Chemie - International Edition, 2007 , vol. 46, # 13 p. 2325 - 2327

Full Text: HTML

Citation Number: 47

Abstract

Transfer RNAs (tRNAs) are key molecules needed for the decoding of the genetic information at the ribosome.[1] The tRNAs contain the four canonical RNA bases plus a large set of modified nucleotides whose function in the tRNA charging and decoding process is largely unknown.[2] Queuosine (Q; 1)[3] and its galactosylated, mannosylated, or amino acid modified derivatives [4](Scheme 1) are important hypermodified RNA bases ...