Helvetica chimica acta

Nucleosides. Part LXI. A Simple Procedure for the Monomethylation of Protected and Unprotected Ribonucleosides in the 2′??O??and 3′??O??Position Using …

H Cramer, W Pfleiderer

Index: Cramer, Hagen; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1996 , vol. 79, # 8 p. 2114 - 2136

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Citation Number: 18

Abstract

Abstract Intensive studies on the diazomethane methylation of the common ribonucleosides uridine, cytidine, adenosine, and guanosine and its derivatives were performed to obtain preferentially the 2′-O-methyl isomers. Methylation of 5′-O-(monomethoxytrityl)-N 2-(4- nitrophenyl) ethoxycarbonyl-O 6-[2-(4-nitrophenyl) ethyl]-guanosine (1) with diazomethane resulted in an almost quantitative yield of the 2′-and 3′-O-methyl isomers which could ...

~84%

~83%

A reliable Pd-mediated hydrogenolytic deprotection of BOM gr...

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A convergent synthesis of 2′-o-methyl uridine

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Synthesis of New 3'-, 5-, and N 4-Modified 2'-O-Methylcytidi...

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Synthesis of C??5 and N??3 arenesulfenyl uridines. Preparati...

[Welch, C. J.; Bazin, H.; Heikkila, J.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 3 p. 203 - 212]

General preparative synthesis of 2′??O??methylpyrimidine rib...

[Ross; Springer; Vasquez; Andrews; Cook; Acevedo Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 765 - 769]