Tetrahedron

A convergent synthesis of 2′-o-methyl uridine

G Parmentier, G Schmitt, F Dolle, B Luu

Index: Parmentier, Gilles; Schmitt, Gaby; Dolle, Frederic; Luu, Bang Tetrahedron, 1994 , vol. 50, # 18 p. 5361 - 5368

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Citation Number: 25

Abstract

A convergent synthesis of 2′-O-methyl uridine (1) is described. The key steps in our synthesis are:(1) a facile obtention of the 2′-O-methyl sugar synthon using totally selective and efficient methylation conditions;(2) a stereoselective high-yield condensation with an uracil derivative, yielding the desired β-form.

~10%

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