Tetrahedron letters

A reliable Pd-mediated hydrogenolytic deprotection of BOM group of uridine ureido nitrogen

BA Aleiwi, M Kurosu

Index: Aleiwi, Bilal A.; Kurosu, Michio Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3758 - 3762

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Citation Number: 10

Abstract

The benzyloxymethyl (BOM) group has been utilized widely in syntheses of a variety of natural and non-natural products. The BOM group is also one of few choices to protect uridine ureido nitrogen. However, hydrogenolytic cleavage of the BOM group of uridine derivatives has been unreliably performed via heterogeneous conditions using Pd catalysts. One of the undesirable by-products formed by Pd-mediated hydrogenation conditions is ...

~94%

~99%

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