RSC Advances

A one-pot process for palladium catalyzed direct C–H acylation of anilines in water using a removable ortho directing group

F Szabó, D Simkó, Z Novák

Index: Szabo, Fruzsina; Simko, Daniel; Novak, Zoltan RSC Advances, 2014 , vol. 4, # 8 p. 3883 - 3886

Full Text: HTML

Citation Number: 9

Abstract

A new mild, practical method for the synthesis of aminobenzophenone derivatives through a three step one-pot reaction sequence involving acylation of anilines, palladium catalyzed cross-dehydrogenative coupling of the formed anilides and the hydrolytic cleavage is reported. The full reaction sequence was performed under aqueous conditions.

 Related Synthetic Route
N-(2-(4-Chlorobenzoyl)phenyl)acetamide Structure

92433-53-9

N-(2-(4-Chlorob...

~%

2-Amino-4'-Chlorobenzophenone Structure

2894-51-1

2-Amino-4'-Chlo...

Acetanilide Structure

103-84-4

Acetanilide

~%

2-Amino-4'-Chlorobenzophenone Structure

2894-51-1

2-Amino-4'-Chlo...

Structure

74497-02-2

~%

2-Amino-4'-Chlorobenzophenone Structure

2894-51-1

2-Amino-4'-Chlo...

N-(2-(3-Chlorobenzoyl)phenyl)acetamide Structure

1335211-11-4

N-(2-(3-Chlorob...

~87%

(2-aminophenyl)-(3-chlorophenyl)methanone Structure

57479-65-9

(2-aminophenyl)...

Acetanilide Structure

103-84-4

Acetanilide

~%

(2-aminophenyl)-(3-chlorophenyl)methanone Structure

57479-65-9

(2-aminophenyl)...

Structure

74497-02-2

~%

(2-aminophenyl)-(3-chlorophenyl)methanone Structure

57479-65-9

(2-aminophenyl)...

N-(2-(2-chlorobenzoyl)phenyl)acetamide Structure

1239986-54-9

N-(2-(2-chlorob...

~%

2-amino-2'-chlorobenzophenone Structure

2894-45-3

2-amino-2'-chlo...

Acetanilide Structure

103-84-4

Acetanilide

~%

2-amino-2'-chlorobenzophenone Structure

2894-45-3

2-amino-2'-chlo...

Structure

74497-02-2

~%

2-amino-2'-chlorobenzophenone Structure

2894-45-3

2-amino-2'-chlo...

2'-Benzoylacetanilide Structure

85-99-4

2'-Benzoylaceta...

~88%

2-Aminobenzophenone Structure

2835-77-0

2-Aminobenzophenone

Structure

74497-02-2

~%

2-Aminobenzophenone Structure

2835-77-0

2-Aminobenzophenone

Acetanilide Structure

103-84-4

Acetanilide

~%

2-Aminobenzophenone Structure

2835-77-0

2-Aminobenzophenone

Acetanilide Structure

103-84-4

Acetanilide

~%

2-aminobutyrophenone Structure

2034-40-4

2-aminobutyrophenone

Structure

74497-02-2

~%

2-aminobutyrophenone Structure

2034-40-4

2-aminobutyrophenone


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