Tetrahedron letters

Synthesis of a new generation reverse transcriptase inhibitor via the BCl 3/GaCl 3-induced condensation of anilines with nitriles (sugasawa reaction)

IN Houpis, A Molina, AW Douglas, L Xavier, J Lynch…

Index: Houpis, Ioannis N.; Molina, Audrey; Douglas, Alan W.; Xavier, Lyndon; Lynch, Joseph; et al. Tetrahedron Letters, 1994 , vol. 35, # 37 p. 6811 - 6814

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Citation Number: 28

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines. ... Chem. Rev., 90 (1990), p. 879 In our hands attempts to acylate the N-Boc protected 4 with nitrile 5 gave none of the desired product 3 ...