Synthesis and evaluation of antileukemic activity of 5-thienyl-or 5-(2-furyl)-2, 3-dihydro-6, 7-bis (hydroxymethyl)-1H-pyrrolizine bis (alkylcarbamates) and derivatives

D Laduree, JC Lancelot, M Robba…

Index: Laduree, Daniel; Lancelot, Jean-Charles; Robba, Max; Chenu, E.; Mathe, G. Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 456 - 461

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Citation Number: 20

Abstract

(2d). Reduction of 2 with lithium aluminum hydride gave the diols 3a, 3b, 3c, and 3d. These diols yielded the corresponding diacetates 4 by treatment with acetic anhydride. The bis (methy1carbamates) 5a, 5b, 5c, and 5d and bis (isopropy1carbamates) 6b and 6c are obtained with the appropriate isocyanates. The 1-substituted pyrrolizines were synthesized, the 1-acetoxy compounds 7b and 7c further transformed into 1-hydroxy (8b, 8c) and 1-oxo ...