Tetrahedron

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

MS Ermolenko, S Guillou, YL Janin

Index: Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L. Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263

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Citation Number: 18

Abstract

We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4-or 5-iodinated-3/5- trifluoromethylpyrazoles building blocks and the use of Suzuki–Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.