Tetrahedron

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

MS Ermolenko, S Guillou, YL Janin

文献索引：Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L. Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263

被引用次数: 18

摘要

We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4-or 5-iodinated-3/5- trifluoromethylpyrazoles building blocks and the use of Suzuki–Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.

20154-03-4

3-三氟甲基吡唑

~6%

~84%

~86%

~38%

~66%

~67%

~87%

~98%

~80%

~23%

~36%

~59%

~73%

~84%

Cyclizations of monocyclic 5-nitropyridin-2 (1H)-ones

[Smolyar; Yutilov Russian Journal of Organic Chemistry, 2008 , vol. 44, # 8 p. 1205 - 1210]