Optimization and Scale-Up of a Novel Process for 2-Aminoindan Hydrochloride Production

D Roche, D Sans, MJ Girgis, K Prasad…

Index: Organic Process Research and Development, , vol. 5, # 2 p. 167 - 175

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Abstract

... Detailed Procedure. ... It is important not to overheat the reaction mixture because of a decomposition process starting at 84 °C. Cool to 25 °C and add a slurry of 2.64 g of dry 10% Pd on activated carbon premixed with 77.40 g of glacial acetic acid ... Filter the top organic layer. ...

~53%

~16%

~15%

Concise syntheses of 2-aminoindans via indan-2-ol

[Goeksu, Sueleyman; Secen, Hasan Tetrahedron, 2005 , vol. 61, # 28 p. 6801 - 6807]

Optimization and Scale-Up of a Novel Process for 2-Aminoinda...

[Roche, Didier; Sans, David; Girgis, Michael J.; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J. Organic Process Research and Development, 2001 , vol. 5, # 2 p. 167 - 175]

Comparison of biological effects of N-alkylated congeners of...

[Cannon, Joseph G.; Perez, Julio A.; Pease, Jonathan P; Long, John Paul; Flynn, Jan R.; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 745 - 749]

Concise syntheses of 2-aminoindans via indan-2-ol

[Tetrahedron, , vol. 61, # 28 p. 6801 - 6807]