Tetrahedron

Concise syntheses of 2-aminoindans via indan-2-ol

S Göksu, H Seçen

Index: Goeksu, Sueleyman; Secen, Hasan Tetrahedron, 2005 , vol. 61, # 28 p. 6801 - 6807

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Citation Number: 22

Abstract

2-Amino-5, 6-dimethoxyindan hydrochloride was synthesized in seven steps and with an overall yield of 48%. Indan-2-ol was converted to 5, 6-dibromo-indan-2-ol in three steps by acetylation, electrophilic bromination and deacetylation. Dimethoxylation of 5, 6- dibromoindan-2-ol with NaOCH3 in the presence of CuI gave 5, 6-dimethoxy-indan-2-ol, which was converted to 2-amino-5, 6-dimethoxyindan hydrochloride by azidation, ...