Regioselective Hydrodebromination of Polybrominated Indoles

G Chelucci, GA Pinna, G Pinna

Index: Chelucci, Giorgio; Pinna, Gerard A.; Pinna, Giansalvo European Journal of Organic Chemistry, 2014 , vol. 2014, # 18 p. 3802 - 3807

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Abstract

Abstract The mixture of sodium borohydride and N, N, N′, N′-tetramethylethylenediamine in combination with a palladium catalyst is a mild and efficient system for the regioselective hydrodebromination of polybrominated indoles with both N-donating and N-withdrawing substituents [N-methyl-and N-(methoxycarbonyl) indoles, respectively].

~60%

~97%

~54%

~92%

~89%

~98%

~61%

~93%

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