Chinese Chemical Letters

A facile synthesis of the oxazolidinone antibacterial agent linezolid

YW Li, Y Liu, YC Jia, JY Yuan

Index: Li, Yan-Wu; Liu, Yan; Jia, Yun-Can; Yuan, Jian-Yong Chinese Chemical Letters, 2013 , vol. 24, # 3 p. 230 - 232

Full Text: HTML

Citation Number: 2

Abstract

Abstract A facile synthetic route of linezolid 1 has been developed. Using commercially available (R)-epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coupling, aminolysis and acetylation reactions. The

~83%

~76%

Large-Scale Synthesis of Singh's Catalyst in a One-Pot Proce...

[Song, Lirong; Chen, Xiaobei; Zhang, Shilei; Zhang, Haoyi; Li, Ping; Luo, Guangshun; Liu, Wenjing; Duan, Wenhu; Wang, Wei Organic Letters, 2008 , vol. 10, # 23 p. 5489 - 5492]

Short and practical enantioselective synthesis of linezolid ...

[Tetrahedron Letters, , vol. 47, # 38 p. 6799 - 6802]

Synthesis and antibacterial activity of linezolid analogues

[Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 6 p. 857 - 859]