Chinese Chemical Letters

A facile synthesis of the oxazolidinone antibacterial agent linezolid

YW Li, Y Liu, YC Jia, JY Yuan

文献索引：Li, Yan-Wu; Liu, Yan; Jia, Yun-Can; Yuan, Jian-Yong Chinese Chemical Letters, 2013 , vol. 24, # 3 p. 230 - 232

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被引用次数: 2

摘要

Abstract A facile synthetic route of linezolid 1 has been developed. Using commercially available (R)-epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coupling, aminolysis and acetylation reactions. The