Diisopropylethylamine mono (hydrogen fluoride) for nucleophilic fluorination of sensitive substrates: synthesis of sevoflurane

…, RA Lessor, LA Rozov, S Afrin, C McCutcheon…

Index: Kudzma; Huang; Lessor; Rozov; Afrin; Kallashi; McCutcheon; Ramig Journal of Fluorine Chemistry, 2001 , vol. 111, # 1 p. 11 - 16

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Citation Number: 11

Abstract

Diisopropylethylamine mono (hydrogen fluoride)(8), which can be prepared by addition of two equivalents of diisopropylethylamine to the complex diisopropylethylamine tris (hydrogen fluoride)(7), is shown to be an effective and selective nucleophilic fluorinating reagent when applied to halogen-exchange reactions of chloromethyl ethers, in particular the conversion of 1, 1, 1, 3, 3, 3-hexafluoroisopropyl chloromethyl ether (3) to the volatile ...