Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl) cyclohexylamines as high affinity. sigma. receptor ligands. Identification of a new class of …

BR De Costa, WD Bowen, A Thurkauf…

Index: De Costa; Rice; Bowen; Thurkauf; Rothman; Band; Jacobson; Radesca; Contreras; Gray; Daly; Iyengar; Finn; Vazirani; Walker Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3100 - 3110

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Citation Number: 39

Abstract

(+)-3-PPP). These compounds showed insignificant affinity for K, dopamine, or PCP receptors, making them valuable tools for the study of u recept0r. s. Furthermore, these compounds also exhibited enantioselectivity ranging from 5-fold for (+)-and (-)-44 to 160-fold for (+)-and (-)-29. Several other compounds showed equivalent selectivity but displayed lower u receptor affinity.