Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl) cyclohexylamines as high affinity. sigma. receptor ligands. Identification of a new class of …
(+)-3-PPP). These compounds showed insignificant affinity for K, dopamine, or PCP receptors, making them valuable tools for the study of u recept0r. s. Furthermore, these compounds also exhibited enantioselectivity ranging from 5-fold for (+)-and (-)-44 to 160-fold for (+)-and (-)-29. Several other compounds showed equivalent selectivity but displayed lower u receptor affinity.
