Synlett

Chiral zirconium alkoxides-mediated asymmetric Meerwein-Ponndorf-Verley cyanation of aldehydes

T Ooi, K Takaya, T Miura, H Ichikawa, K Maruoka

Index: Ooi, Takashi; Takaya, Keisuke; Miura, Tomoya; Maruoka, Keiji Synlett, 2000 , # 1 p. 69 - 70

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Citation Number: 16

Abstract

Abstract: Chiral zirconium alkoxides prepared in situ from Zr (OBut) 4, TADDOL and acetone cyanohydrin in CH2Cl2 effect the enantioselective Meerwein-Ponndorf-Verley cyanation of aldehydes, giving optically active cyanohydrins. The reaction proceeds catalytically with the aid of activated, powdered 4Å molecular sieves. Key words: chiral zirconium alkoxides, Meerwein-Ponndorf-Verley cyanation, aldehydes, acetone cyanohydrin, optically active ...

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