e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron Letters
On the regioselectivity of the reaction of N-methoxycarbonylpyridinium chloride with Grignard reagents: highly regioselective synthesis of 2-substituted N- …
Abstract Whereas alkyl Grignard reagents undergo 1, 2-and 1, 4-additions to N- methoxycarbonylpyridinium chloride in a variable ratio, alkenyl and alkynyl Grignard reagents do the exclusive 1, 2-addition to afford 2-substituted N-methoxycarbonyl-1, 2- dihydropyridines in fair to excellent yields.
