On the regioselectivity of the reaction of N-methoxycarbonylpyridinium chloride with Grignard reagents: highly regioselective synthesis of 2-substituted N- …
Abstract Whereas alkyl Grignard reagents undergo 1, 2-and 1, 4-additions to N- methoxycarbonylpyridinium chloride in a variable ratio, alkenyl and alkynyl Grignard reagents do the exclusive 1, 2-addition to afford 2-substituted N-methoxycarbonyl-1, 2- dihydropyridines in fair to excellent yields.
