Tetrahedron

Tetrabutyl ammonium bromide-mediated benzylation of phenols in water under mild condition

H Wang, Y Ma, H Tian, A Yu, J Chang, Y Wu

Index: Wang, Hailei; Ma, Yuping; Tian, Heng; Yu, Ajuan; Chang, Junbiao; Wu, Yangjie Tetrahedron, 2014 , vol. 70, # 16 p. 2669 - 2673

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Citation Number: 5

Abstract

Abstract Benzylation of phenol was successfully achieved in water under room temperature mediated by tetrabutylammonium bromide (TBAB) for only 2 h affording the corresponding benzyl phenyl ether with good to excellent yields. This protocol is very efficient, simple, avoiding catalysts, easy to work-up after reaction, and especially 'green'.