Benzophenone derivatives: a novel series of potent and selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase

…, RC Bethell, N Cammack, D Charon…

Index: Wyatt, Paul G.; Bethell, Richard C.; Cammack, Nicholas; Charon, Daniel; Dodic, Nerina; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1657 - 1665

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Citation Number: 70

Abstract

A series of benzophenone derivatives has been synthesized and evaluated as inhibitors of HIV-1 reverse transcriptase (RT) and the growth of HIV-1 in MT-4 cells. Through the use of the structure-activity relationships within this series of compounds and computational chemistry techniques, a binding conformation is proposed. The SAR also indicated that the major interactions of lh with the RT enzyme are through hydrogen bonding of the amide ...