Potential antidepressants. Synthesis of 6, 11-dihydrodibenzo [b, e] thiepin-11-yl (dimethylaminomethyl) phenyl ethers, sulfides, amines and some related compounds

…, V Valenta, J Holubek, O Matoušová…

Index: Sindelar, Karel; Valenta, Vladimir; Holubek, Jiri; Matousova, Oluse; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 1 p. 282 - 295

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Abstract

Abstract Reactions of 11-chloro-6, 11-dihydrodibenzo [b, e] thiepin and its 2-bromo derivative with the isomeric (dimethylaminomethyl) phenols,(dimethylaminomethyl) thiophenols, and (dimethylaminomethyl) anilines in toluene afforded the title compounds IIIb, c, Va, VIIIa, b, c, and Xa, b, c. Reactions of 11-chloro-6, 11-dihydrodibenzo [b, e] thiepin and its 2-chloro and 2-methyl derivatives with N, N-dimethyl-2-(4-aminophenoxy) ethylamine ...