Synthesis and in vitro antibacterial activity of 5-halogenomethylsulfonyl-benzimidazole and benzotriazole derivatives

Z Ochal, M Bretner, R Wolinowska…

Index: Ochal, Zbigniew; Bretner, Maria; Wolinowska, Renata; Tyski, Stefan Medicinal Chemistry, 2013 , vol. 9, # 8 p. 1129 - 1136

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Citation Number: 6

Abstract

A series of 5-halogenomethylsulfonylbenzimidazole and benzotriazole derivatives was synthesized as potential antibacterial agents. A new method of synthesis of benzimidazoles was developed. The antimicrobial activities of these compounds were tested against a series of reference and clinical strains. The reference strains include Gram-positive bacteria (S. aureus, S. epidermidis, B. subtilis, B. cereus, E. hirae, M. luteus) and Gram-negative ...